In 2013, Los Angeles Police Department officer Jonathan Ingram (Hideyuki Tanaka) was one of five "Policenauts", police officers who received astronaut training to protect Beyond Coast, humanity's first functional self-supporting space colony. During the test of a new space suit, an accident causes Jonathan to drift into space, presumed dead by his colleagues. In reality, the cryogenic survival system in the suit preserved him, and he is found and revived 25 years later. During that time, Beyond Coast has become the principal development location for potential interstellar travel, and is protected by a dedicated police force dubbed the Beyond Coast Police Department (BCPD).
In 2040, Jonathan has become a private investigator on Earth in Old Los Angeles. He is visited by his former wife Lorraine (Chiyoko Kawashima), who remarried while he was presumed dead. Lorraine asks for Jonathan's help in solving the disappearance of her husband, Kenzo Hojo; the only clues are a torn leaf, a set of capsules, and the word "Plato". Jonathan is reluctant to take her case at first, but after Lorraine leaves his office, she is murdered by a man in a black motorcycle suit. After failing to catch the culprit, Jonathan decides to fulfill Lorraine's final request and travels to Beyond, where he is reunited with his former LAPD partner, BCPD Vice Department chief Ed Brown (Shōzō Iizuka), who agrees to help Jonathan investigate the circumstances surrounding Hojo's disappearance and Lorraine's murder along with Vice Unit members Meryl Silverburgh (Kyoko Terase) and Dave Forrest (Bin Shimada).
During their investigation, Jonathan receives information from Karen (Kikuko Inoue), Lorraine's daughter with Hojo, that Hojo was growing increasingly stressed working at Tokugawa Pharmaceuticals, which is helping research medical solutions to health problems caused by living in space. Jonathan and Ed also run into former Policenauts Gates Becker (Osamu Saka) and Joseph Tokugawa (Iemasa Kayumi), the latter of whom Jonathan suspects of being involved. They receive further leads from a former co-worker of Hojo's; the informant is later killed and used to lure Jonathan and Ed into an unsuccessful booby trap. Hojo's body is eventually found, and Jonathan is framed for the killings. Tokugawa and Becker are revealed to have both been responsible for Jonathan's accident, and the prime movers behind an illegal drug and organ trafficking ring designed to counteract the negative side-effects of being in space for long periods of time.
