The story of the game is similar to that of the second movie, Vampire Hunter D: Bloodlust (which, in turn, is based on the third novel). Essentially, D, a Dhampir (transliterated as Dunpeal) vampire hunter is hired by an old man named Elbourne to save his daughter Charlotte, who was kidnapped by a vampire, Meier Link. If his daughter was already mutated into a vampiress, then D should kill her humanely. Also, Elbourne's son hired a team of human vampire hunters known as the Marcus Brothers to serve as backup. There are a fairly large number of differences between the film and the game, however. The game's story is more streamlined and the whole of the story largely takes place inside of Camila's castle.
Only two of the Barbarois mutants (Benge and Mashira) appear as enemies, Caroline being not featured. Borgoff and Leila were the only members of the Marcus brothers which were notably featured, with Leila actually becoming a playable character at one point; Kyle, Nolt, and Grove make few cameos in cutscenes, and later are found dead. There are 3 possible endings based on the player's actions in-game, 1 of which is similar to the end of the film.
